A case-control study on risk factors associated with death in pregnant women with severe pandemic H1N1 infection

作者：Li Furong; Chen Guoping; Wang Jianjun^*; Liu Hong; Wu Jiabing

来源：BMJ Open, 2012, 2(4): e000827.

DOI：10.1136/bmjopen-2012-000827

Objectives: To describe the risk factors associated with death in pregnant women with severe pandemic H1N1 infection.
Design: Case-control study.
Setting: Anhui, China.
Participants: A total of 46 pregnant women with severe pandemic H1N1 infection were studied during June 2009-April 2011.
Primary and secondary outcome measures: All the cases were confirmed by the clinicians and epidemiologists together based on the positive laboratory result.
Results: Of the seven pregnant women who died of the pandemic H1N1 infection, five (70%) cases were in their third trimester. Twenty-nine (63%) cases from the surviving group were admitted to hospital within 3 days after the onset of symptoms, while only one (2%) case from the death group took the earliest admission 2 days after the onset. There was a significant difference on how soon to be admitted between the death and the surviving groups (OR 0.09, 95% CI 0.01 to 0.68). The median time of administrating corticosteroids was 5 days after the onset in the death group and 3 days in the surviving group showing no significant difference between them (p=0.056).
Conclusions: For the pregnant women with severe p (H1N1) infection, the risk factors associated with death were as follows: the delay of antiviral treatment and being in the third trimester. The corticosteroids therapy appeared to have no effects on preventing the cases from death.

• 出版日期2012