A Longitudinal Study of Association between Adiposity Markers and Intraocular Pressure: The Kangbuk Samsung Health Study

作者：Zhao Di; Kim Myung Hun; Pastor Barriuso Roberto; Chang Yoosoo; Ryu Seungho^*; Zhang Yiyi; Rampal Sanjay; Shin Hocheol; Kim Joon Mo; Friedman David S; Guallar Eliseo; Cho Juhee

来源：PLos One, 2016, 11(1): e0146057.

DOI：10.1371/journal.pone.0146057

Importance
Intraocular pressure (IOP) reduction or stabilization is the only proven method for glaucoma management. Identifying risk factors for IOP is crucial to understand the pathophysiology of glaucoma.
Objective
To examine the associations of change in body mass index (BMI), waist circumference, and percent fat mass with change in intraocular pressure (IOP) in a large sample of Korean adults.
Design, setting and participants
Cohort study of 274,064 young and middle age Korean adults with normal fundoscopic findings who attended annual or biennial health exams from January 1, 2002 to Feb 28, 2010 (577,981 screening visits).
Exposures
BMI, waist circumference, and percent fat mass.
Main Outcome Measure(s)
At each visit, IOP was measured in both eyes with automated noncontact tonometers.
Results
In multivariable-adjusted models, the average increase in IOP (95% confidence intervals) over time per interquartile increase in BMI (1.26 kg/m(2)), waist circumference (6.20 cm), and percent fat mass (3.40%) were 0.18 mmHg (0.17 to 0.19), 0.27 mmHg (0.26 to 0.29), and 0.10 mmHg (0.09 to 0.11), respectively (all P < 0.001). The association was stronger in men compared to women (P < 0.001) and it was only slightly attenuated after including diabetes and hypertension as potential mediators in the model.
Conclusions and Relevance
Increases in adiposity were significantly associated with an increase in IOP in a large cohort of Korean adults attending health screening visits, an association that was stronger for central obesity. Further research is needed to understand better the underlying mechanisms of this association, and to establish the role of weight gain in increasing IOP and the risk of glaucoma and its complications.

• 出版日期2016-1-5