Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease

作者：Kopras Elizabeth; Potluri Veena; Bermudez Mei Ling; Williams Karin; Belcher Scott; Kasper Susan^*

来源：Endocrine-Related Cancer, 2014, 21(2): T1-T12.

DOI：10.1530/ERC-13-0360

• endocrine disruptors
• stem cell/progenitor cell
• cancer stem cell
• organ development
• steroid hormone receptors

Development and fate of the stem cell are regulated by extrinsic signals from the environment. Endocrine-disrupting chemicals which perturb hormonal signaling in utero and during early childhood may cause deregulation of multiple developmental processes, ranging from breakdown of stemcell niche architecture, developmental reprograming and altered stem cell fate to impaired organ and gonad development and sexual differentiation. Therefore, study of the environmental effects on stem cell integrity and normal development is a new and emerging focus for developmental biologists and cell toxicologists. When combined with new human and mouse stem cell-based models, stem cell differentiation dynamics can be studied in more biologically relevant ways. In this study, we review the current status of our understanding of the molecular mechanisms by which endocrine disruptors alter embryonic stemcell and adult stem/progenitor cell fate, organ development, cancer stem cell activity, and tumorigenesis.

• 出版日期2014-4