Anaphylaxis to galacto-oligosaccharides - an evaluation in an atopic population in Singapore

作者：Soh J Y; Huang C H; Chiang W C; Llanora G V; Lee A J; Loh W; Chin Y L C; Tay V Y J; Chan Y H; Dianne D; Lee B W^*

来源：Allergy, 2015, 70(8): 1020-1023.

DOI：10.1111/all.12645

• anaphylaxis
• galacto-oligosaccharide
• prebiotic

Anaphylaxis to galacto-oligosaccharides (GOS), a prebiotic, has been described in atopic patients following its supplementation in commercial milk formula in South-East Asia. The epidemiology of this usual allergy to a carbohydrate is unknown. This study evaluated the prevalence of allergy to two formulations of commercial GOS, Vivinal GOS (vGOS) and Oligomate, in an atopic cohort. Atopic subjects (n=487) from two specialist allergy clinics were surveyed via structured questionnaire and underwent skin prick tests to GOS. Subjects with positive skin prick tests to GOS (n=30, 6.2%) underwent basophil activation tests, and a subset (n=13) underwent oral challenge tests to both formulations of GOS. Six subjects had positive challenges to vGOS; and none to Oligomate. By extrapolating the BAT and oral challenge results, the prevalence of allergy to vGOS is estimated at up to 3.5% (95% CI 2.2-5.5%) of our atopic population. Our findings show that GOS allergy may be common amongst atopics in Singapore.

• 出版日期2015-8