A retrospective study of reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors and sex cord-stromal tumors

作者：Zhang, Ning; Chen, Ruifang; Hua, Keqin^*; Zhang, Ying^*

来源：Journal of Ovarian Research, 2017, 10(1): 52.

DOI：10.1186/s13048-017-0348-x

• Malignant germ cell tumors
• Malignant sex cord-stromal tumors
• Fertility-sparing surgery
• Postoperative adjuvant chemotherapy
• Reproductive outcomes

Background: To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST).
Methods: Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed.
Results: Average follow up was (86.3 +/- 34.4) months. Average diagnosed age was (25.3 +/- 3.5) years. Average chemotherapy course was (4.4 +/- 1.3) times. Patients are all living. Thirty one patients (75.6%) reported normal menstrual cycles. Twelve patients (29.3%) wished to conceive, 10 (83.3%) naturally conceived and 8 (66.7%) had lived birth.
Conclusions: Reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in MOGCT and SCST are favorable, meanwhile education and consultation is needed.

• 出版日期2017-7-27
• 单位复旦大学