A phase I study of sirolimus and bevacizumab in patients with advanced malignancies

作者：Cohen E E W^*; Sharma M R; Janisch L; Llobrera M; House L; Wu K; Ramirez J; Fleming G F; Stadler W M; Ratain M J

来源：European Journal of Cancer, 2011, 47(10): 1484-1489.

DOI：10.1016/j.ejca.2011.02.017

• Sirolimus
• Bevacizumab
• Phase I

Background: We performed a single institution, phase I study of sirolimus and bevacizumab, in order to determine the dose limiting toxicity (DLT) and recommended phase II doses.
Patients and methods: Eligible patients had previously treated advanced malignancies and were enrolled in three cohorts. Sirolimus 90 mg PO weekly (45 mg on days 1 and 2) was combined with bevacizumab 7.5 mg/kg (cohort #1) or bevacizumab 15 mg/kg (cohort #2) IV g3weeks. Sirolimus 4 mg PO daily was combined with bevacizumab 15 mg/kg IV q3weeks (cohort #3).
Results: Twenty-eight patients enrolled. The most common tumour types were colorectal (21%), head/neck (14%), and renal cell (11%). No DLTs were observed in cohorts #1 (4 patients) and #2 (12 patients), while two DLTs (grade 3 confusion and grade 3 fatigue) were observed in the first six patients in cohort #3 (12 patients). The most common grade 3 toxicities were fatigue (18%), hypertension (14%) and anorexia (11%). There were no responses, but one patient has had stable disease for 78 weeks.
Conclusions: The combination of sirolimus and bevacizumab at full doses is tolerable in the majority of patients. The availability and cost of sirolimus compared with other mTOR inhibitors make this an attractive agent to combine with bevacizumab.

• 出版日期2011-7