Microwave promoted one-pot synthesis of novel A-ring fused steroidal dehydropiperazines

作者：Borthakur Moyurima; Barthakur Madan G; Boruah Romesh C^*

来源：Steroids, 2008, 73(5): 539-542.

DOI：10.1016/j.steroids.2008.01.005

• fused steroids
• ethylenediamine
• dehydropiperazine
• microwave

The preparation of ring-A fused steroidal dehydropiperazine at the 3,4-position is herein described. The novel steroidal dehydropiperazines were prepared from the annulation reaction of ethylenediamine with 3-keto-4-en steroids in a one-pot reaction under microwave irradiation. The key step involves base catalysed aerial oxidation of the C-6 methylene group followed by cyclocondensation of ethylenediamine via Michael addition reaction.

• 出版日期2008-5