Binding and backbone dynamics of protein under topological constraint: calmodulin as a model system

作者：Katyal Priya; Yang Yongkun; Fu You Jun; Iandosca Jennifer; Vinogradova Olga^*; Lin Yao^*

来源：Chemical Communications, 2018, 54(64): 8917-8920.

DOI：10.1039/c8cc03977a

Herein we present the effect of artificially imposed topological constraint on calmodulin (CaM) backbone dynamics and its molecular recognition behavior. While backbone dynamics of CaM remain largely unperturbed, the thermodynamic profile of CaM binding to the smooth-muscle myosin light-chain kinase (smMLCK) peptide is modulated significantly.

• 出版日期2018-8-18