Assessment of the association between glycemic variability and diabetes-related complications in type 1 and type 2 diabetes

作者：Smith Palmer J^*; Braendle M; Trevisan R; Federici M Orsini; Liabat S; Valentine W

来源：Diabetes Research and Clinical Practice, 2014, 105(3): 273-284.

DOI：10.1016/j.diabres.2014.06.007

• Glycemic variability
• Microvascular complications
• Macrovascular complications

Chronic hyperglycemia is the main risk factor for the development of diabetes-related complications in both type 1 and type 2 diabetes, but it is thought that frequent or large glucose fluctuations may contribute independently to diabetes-related complications.
A systematic literature review was performed using the PubMed, EMBASE and Cochrane Library databases with searches limited to studies published from June 2002 to March 2014, in English and including >= 50 patients. Twenty eight articles were included in the final review.
Eighteen studies reported the association between glucose variability and diabetes-related complications exclusively in type 2 diabetes. A positive association between increased variability and microvascular complications and coronary artery disease was consistently reported. Associations between glucose variability and other macrovascular complications were inconsistent in type 2 diabetes.
Seven studies examined the association between glucose variability and complications exclusively in type 1 diabetes. Increased glucose variability appears to play a minimal role in the development of micro- and macrovascular complications in type 1 diabetes.
Consistent findings suggest that in type 2 diabetes glucose variability is associated with development of microvascular complications. The role of increased glucose variability in terms of microvascular and macrovascular complications in type 1 diabetes is less clear; more data in are needed.

• 出版日期2014-9