Anti-Inflammatory Effect of Pristimerin on Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophages

作者：Kim Hyeon Jin; Park Geun Mook; Kim Jin Kyung^*

来源：Archives of Pharmacal Research, 2013, 36(4): 495-500.

DOI：10.1007/s12272-013-0054-1

• Pristimerin
• Inflammation
• Nuclear factor-kappa B
• Mitogen-activated protein kinase
• Inflammatory response

Pristimerin, a quinonemethide triterpenoid derived from Celastraceae and Hippocrateaceae, has recently been found to suppress tumor promotion, metastasis and angiogenesis. In the present study, we evaluated the anti-inflammatory potentials of pristimerin in a cell culture system. Pristimerin suppressed not only the generation of nitric oxide (NO) and prostaglandin E-2, but also the expression of inducible NO synthase and cyclooxygenase-2 induced by lipopolysacharide (LPS) in murine macrophage RAW264.7 cells. Similarly, pristimerin inhibited the release of pro-inflammatory cytokines, namely, tumor necrosis factor-alpha and interleukin-6, induced by LPS. The underlying mechanism of the anti-inflammatory action of pristimerin was correlated with down-regulation of nuclear factor-kappa B and the mitogen-activated protein kinase signal pathway.

• 出版日期2013-4