Nanotechnology for delivery of peptide nucleic acids (PNAs)

作者：Gupta Anisha; Bahal Raman; Gupta Meera; Glazer Peter M^*; Saltzman W Mark^*

来源：Journal of Controlled Release, 2016, 240: 302-311.

DOI：10.1016/j.jconrel.2016.01.005

• Nanoparticles
• Peptide nucleic acids
• Gene editing
• Antisense therapy

Over the past three decades, peptide nucleic acids have been employed in numerous chemical and biological applications. Peptide nucleic acids possess enormous potential because of their superior biophysical properties, compared to other oligonucleotide chemistries. However, for therapeutic applications, intracellular delivery of peptide nucleic acids remains a challenge. In this review, we summarize the progress that has been made in delivering peptide nucleic acids to intracellular targets. In addition, we emphasize recent nanoparticle-based strategies for efficient delivery of conventional and chemically-modified peptides nucleic acids.

• 出版日期2016-10-28