Selected regulation mechanisms of corpus luteum regression

作者：Blaszczyk B^*; Udala J; Lasota B

来源：Medycyna Weterynaryjna, 2000, 56(5): 288-292.

• corpus luteum
• regression
• apoptosis

The corpus luteum is an endocrine organ that exhibits extremely rapid growth, development, and regression during the course of each oestrus cycle. At the end of the luteal phase there is an orderly sequence of functional and structural changes in the corpus luteum connected with its regression. This article focuses on selected mechanisms controlling these changes.
In these mechanisms, apart from central regulation, the essential role of local monocytes/macrophages and endothelial cells is stressed, as well as intercellular interactions. The research of the last years shows that corpus luteum regression is related to apoptosis. The functional changes that have been initialized by prostaglandin F-2 alpha are accompanied by the activation of immunological system cells, which while relieving cytokines work like local regulators in remodeling the corpus luteum. Consequently, metabolic changes, the disappearance of luteal tissue and the final expiration of progesterone production occur.

• 出版日期2000-5