Advances in the preparation of porous polymer monoliths in capillaries and microfluidic chips with focus on morphological aspects

作者：Nischang Ivo^*; Brueggemann Oliver; Svec Frantisek

来源：Analytical and Bioanalytical Chemistry, 2010, 397(3): 953-960.

DOI：10.1007/s00216-010-3550-x

• Confinement
• Miniaturization
• Morphology
• Open tubular
• Porous polymer monolith
• Wall effect

Porous polymer monoliths have emerged as unique materials for many applications, including liquid-chromatographic analyses at an unrivaled speed, solid-phase extraction, and enzyme immobilization in capillary and microfluidic chip format. This article reviews the state of the art in the preparation of monoliths in narrow-bore capillaries and microfluidic chips and their miniaturization under conditions of spatial confinement. New developments in their preparation mainly using free radical polymerization techniques with a focus on morphological aspects in view of homogeneous porous materials are described. The suitability of monoliths for analysis of both large and small molecules is also discussed.

• 出版日期2010-6