An efficient approach to the synthesis of water-soluble cyanine dyes using poly(ethylene glycol) as a soluble support

作者：Jiang Lin Ling; Dou Li Fang; Li Bao Lin^*

来源：Tetrahedron Letters, 2007, 48(33): 5825-5829.

DOI：10.1016/j.tetlet.2007.06.060

• polymer-supported synthesis
• water-soluble cyanine dyes
• PEG
• cleavage

An efficient synthesis approach to unsymmetrical water-soluble cyanine dyes has been established. Loading and activation of sulfoindolenium to poly(ethylene glycol) (PEG) have been achieved via a simple strategy. Cyanine dyes are released by the attack of heterocyclic carbon nucleophile and the cleavage of PEG-bound hemicyanine. The efficient approach delivers cyanine dyes in high purity without the nontrivial chromatographic separation.

• 出版日期2007-8-13
• 单位陕西师范大学