An unexpected route toward the synthesis of spiro-benzo[b]acridine-furan derivatives

作者：Ghadari Rahim; Hajishaabanha Fatemeh; Mahyari Mojtaba; Shaabani Ahmad^*; Khavasi Hamid Reza

来源：Tetrahedron Letters, 2012, 53(31): 4018-4021.

DOI：10.1016/j.tetlet.2012.05.107

• Spiro-benzo[b]acridine-6,2 '-furan
• Hetero-Diels-Alder
• Heterocycle
• Multicomponent reaction
• Isocyanide

A facile and straightforward procedure for the synthesis of spiro-benzo[b]acridine-6,2'-furan derivatives via the reaction between benzo[b]acridine-6,11-dione, electron-deficient acetylenic compounds, and an isocyanide is described. The benzo[b]acridine-6,11-dione is obtained from the reaction between 2-(aminomethyl)aniline and 2-hydroxynaphthalene-1,4-dione via an unexpected reaction pathway. The products are synthesized in medium to high yields and no complicated purification is required.

• 出版日期2012-8-1