Anti-neuronal and stress-induced-phosphoprotein 1 antibodies in neuro-Behcet's disease

作者：Vural Burcak; Ugurel Elif; Tuzun Erdem^*; Kurtuncu Murat; Zuliani Luigi; Cavus Filiz; Icoz Sema; Erdag Ece; Gul Ahmet; Gure Ali O; Vincent Angela; Ozbek Ugur; Eraksoy Mefkure; Akman Demir Gulsen

来源：Journal of Neuroimmunology, 2011, 239(1-2): 91-97.

DOI：10.1016/j.jneuroim.2011.08.008

• Behcet's disease
• Neuro-Behcet's disease
• Anti-neuronal antibody
• Stress-induced-phosphoprotein 1
• Antibody
• Autoimmunity

No disease-specific neuronal antibodies have so far been defined in neuro-Behcet's disease (NBD). Immunohistochemistry and immunocytochemistry studies showed antibodies to hippocampal and cerebellar molecular layers and the surface antigens of cultured hippocampal neurons in sera and/or cerebrospinal fluids (CSF) of 13 of 20 NBD and 6 of 20 BD patients but not in multiple sclerosis or headache controls. Screening with a protein macroarray led to identification of stress-induced-phosphoprotein-1 (STIP-1) as an antigenic target. High-titer STIP-1-antibodies were detected in 6 NBD patients' sera but not in controls. These results suggest that neuronal antibodies could be useful as diagnostic biomarkers in NBD.

• 出版日期2011-10-28