Anti-inflammatory actions of a taurine analogue, ethane beta-sultam, in phagocytic cells, in vivo and in vitro

作者：Ward Roberta J^*; Lallemand Frederic; de Witte Philippe; Crichton Robert R; Piette Jacques; Tipton Keith; Hemmings Karl; Pitard Arnaud; Page Mike; Della Corte Laura; Taylor Deanna; Dexter David

来源：Biochemical Pharmacology, 2011, 81(6): 743-751.

DOI：10.1016/j.bcp.2010.12.030

• Taurine
• Anti-inflammatory action
• Ethane-beta sultam
• Nitric oxide
• Glutamate

The ability of a taurine prodrug, ethane beta-sultam, to reduce cellular inflammation has been investigated, in vitro, in primary cultures of alveolar macrophages and an immortilised N9 microglial cell line and in vivo in an animal model of inflammation and control rats. Ethane beta-sultam showed enhanced ability to reduce the inflammatory response in alveolar macrophages, as assayed by the lipopolysaccharide-stimulated-nitric oxide release, (LPS stimulated-NO), in comparison to taurine both in vitro (10 nM, 50 nM) and in vivo (0.15 mmol/kg/day by gavage). In addition, ethane beta-sultam, (50, 100 and 1000 nM) significantly reduced LPS-stimulated glutamate release from N9 microglial cells to a greater extent than taurine. The anti-inflammatory response of taurine was shown to be mediated via stabilisation of IkB alpha. The use of a taurine prodrug as therapeutic agents, for the treatment of neurological conditions, such as Parkinson's and Alzheimer's disease and alcoholic brain damage, where activated phagocytic cells contribute to the pathogenesis, may be of great potential.

• 出版日期2011-3-15