Development of an activity disease score in patients with uveitis (UVEDAI)

作者：Pato Esperanza; Auxiliadora Martin Martinez Ma; Castello Adela; Mendez Fernandez Rosalia; Munoz Fernandez Santiago; Cordero Coma Miguel; Martinez Costa Lucia; Valls Elia; Reyes Miguel; Francisco Felix; Esteban Mar; Fonollosa Alex; Sanchez Alonso Fernando; Fernandez Espartero Cruz; Diaz Valle Teresa; Miguel Carrasco Jose; Beltran Catalan Emma; Hernandez Garfella Marisa; Victoria Hernandez Maria; Pelegrin Laura; Blanco Ricardo; Diaz Valle David

来源：Rheumatology International, 2017, 37(4): 647-656.

DOI：10.1007/s00296-016-3593-1

• Uveitis
• Activity index
• Ocular inflammation
• Outcome measures

To develop a disease activity index for patients with uveitis (UVEDAI) encompassing the relevant domains of disease activity considered important among experts in this field. The steps for designing UVEDAI were: (a) Defining the construct and establishing the domains through a formal judgment of experts, (b) A two-round Delphi study with a panel of 15 experts to determine the relevant items, (c) Selection of items: A logistic regression model was developed that set ocular inflammatory activity as the dependent variable. The construct "uveitis inflammatory activity" was defined as any intraocular inflammation that included external structures (cornea) in addition to uvea. Seven domains and 15 items were identified: best-corrected visual acuity, inflammation of the anterior chamber (anterior chamber cells, hypopyon, the presence of fibrin, active posterior keratic precipitates and iris nodules), intraocular pressure, inflammation of the vitreous cavity (vitreous haze, snowballs and snowbanks), central macular edema, inflammation of the posterior pole (the presence and number of choroidal/retinal lesions, vascular inflammation and papillitis), and global assessment from both (patient and physician). From all the variables studied in the multivariate model, anterior chamber cell grade, vitreous haze, central macular edema, inflammatory vessel sheathing, papillitis, choroidal/retinal lesions and patient evaluation were included in UVEDAI. UVEDAI is an index designed to assess the global ocular inflammatory activity in patients with uveitis. It might prove worthwhile to motorize the activity of this extraarticular manifestation of some rheumatic diseases.

• 出版日期2017-4