Arsenic trioxide - An old drug rediscovered

作者：Emadi Ashkan; Gore Steven D^*

来源：Blood Reviews, 2010, 24(4-5): 191-199.

DOI：10.1016/j.blre.2010.04.001

• Arsenic trioxide (As2O3)
• Acute promyelocytic leukemia (APL)
• Differentiation
• Apoptosis
• Reactive oxygen species
• Induction and consolidation chemotherapy
• Multiple myeloma
• T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell leukemia-lymphoma (ATL)
• Myelodysplastic syndrome (MDS)

Over the last 17 years, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (As2O3) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, the role of As2O3 in front-line therapy is under investigation. Recent trials in the US have demonstrated that the addition of As2O3 to standard treatment regimens improves survival outcomes in patients with APL and may allow a reduction in cytotoxic chemotherapy exposure. As2O3 has also shown efficacy in other malignancies, particularly multiple myeloma and myelodysplastic syndromes. Therapeutic doses of As2O3 are well tolerated, with no evidence of long-term toxicity. Adverse events include APL differentiation syndrome, electrocardiographic abnormalities, and mild elevations in liver enzymes. This review highlights trials investigating the role of As2O3 in induction and consolidation for newly diagnosed APL, as well as its role in other hematologic malignancies. The chemistry, mechanisms of action, and clinical side effects of As2O3 are also discussed.

• 出版日期2010-9