Allergens of weed pollen: An overview on recombinant and natural molecules

作者：Gadermaier Gabriele^*; Hauser Michael; Ferreira Fatima

来源：Methods, 2014, 66(1): 55-66.

DOI：10.1016/j.ymeth.2013.06.014

• Ragweed
• Mugwort
• Parietaria
• IgE binding
• Recombinant allergen
• Hypoallergen
• Allergy diagnosis and therapy

Weeds represent a botanically unrelated group of plants that usually lack commercial or aesthetical value. Pollen of allergenic weeds are able to trigger type I reactions in allergic patients and can be found in the plant families of Asteraceae, Amaranthaceae, Plantaginaceae, Urticaceae, and Euphorbiaceae. To date, 34 weed pollen allergens are listed in the IUIS allergen nomenclature database, which were physicochemically and immunologically characterized to varying degrees. Relevant allergens of weeds belong to the pectate lyase family, defensin-like family, Ole e 1-like family, non-specific lipid transfer protein 1 family and the pan-allergens profilin and polcalcins. This review provides an overview on weed pollen allergens primarily focusing on the molecular level. In particular, the characteristics and properties of purified recombinant allergens and hypoallergenic derivatives are described and their potential use in diagnosis and therapy of weed pollen allergy is discussed.

• 出版日期2014-3-1