An anonymous unlinked sero-prevalence survey of HIVHCV in an urban Emergency Department

作者：Mohammed Debbie Y^*; Martin Eugene; Sadashige Charlotte; Jaker Michael; Paul Sindy

来源：Journal of Clinical Virology, 2013, 58: E19-E23.

DOI：10.1016/j.jcv.2013.08.025

• Prevalence HIVHCV antibody
• Anonymous unlinked sero-survey
• Emergency department

Background: In 2002, the sero-prevalence of human immunodeficiency virus-1 (HIV) in the Emergency Department (ED), University Hospital, Newark, New Jersey was 10.4%. Both HIV and hepatitis C virus (HCV) are transmitted by injection drug use (IDU) or sexual contact. However, the degree of concurrent positive HCV antibody status in HIV-infected ED patients is unknown.
Objectives: In this study we determined the sero-prevalence of HIV and HIVHCV in HIV-positive patients in the ED. Study design: A cross-sectional study using an anonymous sero-prevalence survey was conducted from 71112008 to 812312008. Medical records were reviewed and de-identified; remnant blood specimens were also de-identified and tested for HIV antibody, and if positive, HCV antibody.
Results: Of 3488 specimens, 225 (6.5%, 95% CI: 5.7-7.3%) were positive for HIV antibody. Seventy-four patients 741225 (32.9%, 95% CI: 33.8-46.5%) were unaware of their sero-positivity. Forty percent of HIV positive patients (901225, 95% CI: 33.8-46.5%) were HCV antibody positive. The highest seroprevalence of HIVHCV antibody was among older patients (>45 years), and patients with positive urine toxicology and elevated liver function tests.
Discussion: Given the high prevalence of HIV and HIVHCV antibody in the ED, routine testing is important for patients >45 years with positive urine toxicology and elevated liver function tests. C) 2013 Elsevier B.V.

• 出版日期2013-12