Determination of Asymmetric Dimethylarginine by Using Organic Semiconductor-Based Molecularly Imprinted Polymer Film

作者：Malyshev Valerii; Michota Kaminska Agnieszka; Shao Shuai; D'Souza Francis; Noworyta Krzysztof^*

来源：ECS Journal of Solid State Science and Technology, 2018, 7(7): Q3189-Q3195.

DOI：10.1149/2.0271807jss

A simple and sensitive chemosensor for the determination of asymmetric dimethylarginine (ADMA) was fabricated and tested. In this chemosensor, an electrochemically deposited molecularly imprinted polymer film of thiophene-based organic semiconductor served as the recognition unit. Analytical parameters of the chemosensor were tested with use of voltammetric and impedimetric signal transduction. The devised chemosensor responded linearly from 0.3 to 2.2 mu M, with LOD of 0.3 or 0.4 mu M for DPV and EIS transduction, respectively. Moreover, the chemosensor operated in the presence of excess of interferences. The determined analytical parameters indicated applicability of the chemosensor for determination of ADMA in body fluids.

• 出版日期2018