Alcohol drinking and all cancer mortality: a meta-analysis

作者：Jin, M.; Cai, S.; Guo, J.; Zhu, Y.; Li, M.; Yu, Y.; Zhang, S.; Chen, K.^*

来源：Annals of Oncology, 2013, 24(3): 807-816.

DOI：10.1093/annonc/mds508

• alcohol drinking
• all cancer
• categorical meta-analysis
• dose-response meta-analysis
• mortality
• systemic review

Background: Epidemiological studies have suggested an inconsistent relationship between alcohol drinking and risk of all cancer mortality. As far as we know, no meta-analysis has been conducted to explore this issue. @@@ Patients and methods: We carried out a PubMed search to find relevant articles published before April 2012 in English. Categorical and dose response meta-analyses were conducted to identify the impact of alcohol drinking on all cancer mortality. Potential sources of heterogeneity were detected by meta-regression and stratification analyses. Sensitivity and cumulative meta-analyses were also carried out. @@@ Results: Eighteen independent cohort studies met the inclusion criteria. Compared with non/occasional drinkers, the pooled relative risks (RRs) were 0.91 [95% confidence interval (CI) 0.89-0.94] for light, 1.02 (95% CI 0.99-1.06) for moderate, and 1.31(95% CI 1.23-1.39) for heavy drinkers. Former drinkers presented a higher risk (RR = 1.32, 95% CI 1.15-1.50) than current drinkers (RR = 1.06, 95% CI 0.98-1.16). There was a J-shaped relationship between all cancer mortality and alcohol consumption in males but not in females. @@@ Conclusions: This meta-analysis confirms the health hazards of heavy drinking (>= 50 g/day) and benefits of light drinking (<12.5 g/day). Large-sample, well-designed, prospective epidemiological studies, especially on heavy drinking among women, should be developed in future.

• 出版日期2013-3
• 单位浙江大学