Young age increases the risk of lymph node positivity in papillary thyroid cancer patients: a SEER data-based study

作者：Wang, Jing; Liu, Jianjun; Pan, Huayuan; Jiang, Chenghao; Liu, Song; Zhu, Zhengzhi; Fang, Jing; Zheng, Xucai; Hong, Shikai; Wang, Shengying^*

来源：Cancer Management and Research, 2018, 10: 3867-3873.

DOI：10.2147/CMAR.S167774

• papillary thyroid cancer
• age at diagnosis
• lymph node positivity
• lymph node ratio
• recurrence
• Surveillance
• Epidemiology
• and End results

Introduction: Currently in papillary thyroid cancer (PTC), the correlation between lymph node positivity (LN+) and patient's age at diagnosis is still inconclusive. The aim of this study was to investigate whether younger PTC patients had higher LN+ rates. @@@ Patients and methods: From the 1998-2013 Surveillance, Epidemiology, and End Results database, we analyzed PTC patients with at least 1 LN examined. The patients were divided into 5 groups by age separately for each T stage: <= 30; 31-40; 41-50; 51-60; >60 years. @@@ Results: A total of 46,077 PTC patients were identified, including 8,386 (18.2%) patients aged <= 30 years, 10,971 (23.8%) patients aged 31-40 years, 11,646 (25.3%) patients aged 41-50 years, 8,596 (18.7%) patients aged 51-60 years, and 6,478 (14.1%) patients aged >60 years. In each T stage, LN+ rates were inversely associated with age at diagnosis, which was validated by multivariate logistic regression analysis (p<0.001). In addition, the subset of patients 30 or younger had the highest lymph node ratio compared with other subsets (p<0.001). @@@ Conclusion: We identified that younger PTC patients have an increased predisposition for LN+ regardless of T stage. This finding could help surgeons to select the optimal treatment for younger PTC patients.

• 出版日期2018
• 单位中国科学技术大学