Detecting and Treating Clostridium Difficile Infections in Patients with Inflammatory Bowel Disease

作者：Ananthakrishnan Ashwin N^*

来源：Gastroenterology Clinics of North America, 2012, 41(2): 339-+.

DOI：10.1016/j.gtc.2012.01.003

• Inflammatory bowel disease
• Clostridium difficile
• Crohn disease
• Ulcerative colitis

A cohort that appears to be at a higher risk for Clostridium difficile infection (CDI) and particularly vulnerable to the morbidity and mortality associated with it are patients with underlying inflammatory bowel diseases (IBD). Diagnosis requires demonstration of the toxin from a diarrhea stool sample. Mild CDI can be treated with oral metronidazole, whereas severe disease should be treated with oral vancomycin. Management of recurrent CDI remains challenging. Newer drugs are now available that appear to be effective with lower risk of disease recurrence. Specific treatment trials and prospective studies of CDI in patients with IBD are warranted.

• 出版日期2012-6