Nesfatin-1 and other hormone alterations in polycystic ovary syndrome

作者：Deniz Rulin; Gurates Bilgin; Aydin Suleyman^*; Celik Husnu; Sahin Ibrahim; Baykus Yakup; Catak Zekiye; Aksoy Aziz; Citil Cihan; Gungor Sami

来源：Endocrine, 2012, 42(3): 694-699.

DOI：10.1007/s12020-012-9638-7

• PCOS
• Nesfatin-1
• Ferriman-Gallwey scores

Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 +/- A 0.36 ng/mL) than healthy controls (2.22 +/- A 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman-Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS.

• 出版日期2012-12