Antibiotic Killing through Incomplete DNA Repair

作者:ter Kuile Benno H*; Hoeksema Marloes
来源:Trends in Microbiology, 2018, 26(1): 2-4.
DOI:10.1016/j.tim.2017.11.006

摘要

Two recent studies show that incomplete repair of DNA damage due to oxidized nucleotides is crucial for reactive oxygen species (ROS)-related antimicrobial lethality. Using widely different experimental approaches they both reach the same conclusions on the role of downstream ROS production in cell killing upon exposure to bactericidal antimicrobials.

  • 出版日期2018-1