Announcing the 2018 Toxins Travel Awards for Post-Doctoral Fellows

作者：Fox Jay W^*

来源：Toxins, 2018, 10(1): 46.

DOI：10.3390/toxins10010046

• Enniatin B
• broiler chicken
• chronic dietary intake
• carry-over
• liver residue
• intestinal toxicity
• Chronic dietary intake of the Fusarium mycotoxin enniatin B in broiler chickens has a low impact on the intestinal morphometry
• Above
• histopathological examination of the liver did not reveal abnormalities and carry-over of enniatin B from feed into the liver was limited

The Fusarium mycotoxin enniatin B (ENN B) is a so-called emerging mycotoxin frequently contaminating poultry feed. To investigate the impact of chronic ENN B exposure on animal health, broiler chickens were fed either a diet naturally contaminated with ENN B (2352 mu g/kg) or a control diet (135 mu g/kg) for 2, 7, 14, or 21 days. ENN B concentrations were determined in plasma and liver using a validated ultra-high performance liquid chromatographytandem mass spectrometry UHPLC-MS/MS method. Liver was evaluated histologically, and the villus length and crypt depth of the duodenum, jejunum, and ileum were measured. Histopathology of the livers did not reveal major abnormalities. Feeding an ENN B-contaminated diet could possibly inhibit the proliferation of enterocytes in the duodenal crypts, but did not affect villus length, crypt depth, or villus length-crypt depth ratio of the jejunum and ileum. ENN B levels in plasma and liver were significantly higher in the ENN B-fed group and ranged between <25-264 pg/mL and <0.05-0.85 ng/g, respectively. ENN B carry-over rates from feed to liver tissue were 0.005-0.014% and 0.034-0.109% in the ENN B and control group, respectively. Carry-over rates were low and indicated a limited contribution of poultry tissue-derived products to the total dietary ENN B intake for humans. The above results support the opinion of the European Food Safety Authority stating that adverse health effects from ENN B in broiler chickens are unlikely.

• 出版日期2018-1