Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway

作者：Steiert Sabrina A; Zissler Ulrich M^*; Chaker Adam M; Esser von Bieren Julia; Dittlein Daniela; Guerth Ferdinand; Jakwerth Constanze A; Piontek Guido; Zahner Catherine; Drewe Juergen; Traidl Hoffmann Claudia; Schmidt Weber Carsten B; Gilles Stefanie

来源：Biofactors, 2017, 43(3): 388-399.

DOI：10.1002/biof.1349

• human nasal epithelial cells
• microbial patterns
• petasin
• viral inflammation
• cytokines
• STAT signalling

Ze339, an herbal extract from Petasites hybridus leaves is effective in treatment of allergic rhinitis by inhibition of a local production of IL-8 and eicosanoid LTB4 in allergen-challenged patients. However, the mechanism of action and anti-inflammatory potential in virally induced exacerbation of the upper airways is unknown. This study investigates the anti-inflammatory mechanisms of Ze339 on primary human nasal epithelial cells (HNECs) upon viral, bacterial and pro-inflammatory triggers. To investigate the influence of viral and bacterial infections on the airways, HNECs were stimulated with viral mimics, bacterial toll-like-receptor (TLR)-ligands or cytokines, in presence or absence of Ze339. The study uncovers Ze339 modulated changes in pro-inflammatory mediators and decreased neutrophil chemotaxis as well as a reduction of the nuclear translocation and phosphorylation of STAT molecules. Taken together, this study suggests that phyto drug Ze339 specifically targets STAT-signalling pathways in HNECs and has high potential as a broad anti-inflammatory drug that exceeds current indication.

• 出版日期2017-6