Murine models to study Clostridium difficile infection and transmission

作者：Lawley Trevor D; Young Vincent B^*

来源：Anaerobe, 2013, 24: 94-97.

DOI：10.1016/j.anaerobe.2013.09.008

• Clostridium difficile
• Antibiotic-associated diarrhea
• Disease
• Transmission
• Spore
• Microbiota

Clostridium difficile is the leading cause of antibiotic-associated diarrhea in healthcare facilities worldwide. C difficile infections are difficult to treat because of the high rate of disease recurrence after antibiotic therapy, leaving few treatment options for patients. C difficile is also difficult to contain within a healthcare setting due to a highly-transmissible, resistant spore form that challenges standard infection control measures. The recent development of murine infection models to study the interactions between C difficile, the host and the microbiota are providing novel insight into the mechanisms of pathogenesis and transmission that should guide the development of therapies and intervention measures.

• 出版日期2013-12