A method for extracting period similar to 10 modulations from DNA sequence correlations applied to the Drosophila melanogaster genome

作者：Guerra J C O^*; Licinio P

来源：Genetics and Molecular Research, 2012, 11(3): 2835-2846.

DOI：10.4238/2012.August.24.8

• Nucleotide correlations
• Irreducible correlations
• Period similar to 10 modulation
• Nucleosome sequence
• Linker DNA

Nucleosome DNA packaging and positioning within the Drosophila melanogaster genome imposes a weak modulation, with a period of about 10 bp in the genomic composition correlations. We present formalism for extracting such modulations from an irreducible set of six correlation functions calculated along the D. melanogaster genome. These modulations were seen to be stronger for the irreducible self-correlation C-zz(k) (strong-weak binding). Using an FFT procedure, we show that the period similar to 10 modulation extracted from such self-correlation is viewed to be an oscillation with period similar to 10.9 overmodulated by an oscillation with period similar to 153. This behavior of the modulation reflects the organization of the eukaryotic genomic DNA. But, since the period similar to 10 modulation dies for k similar to 150, the constraints imposed by the nucleosome arrangement over the nucleosome sequence composition must be weak, provided that such constraints are the sources for the modulations.

• 出版日期2012