Changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer

作者：Wang, Lin-Bo; Jiang, Zhi-Nong; Fan, Miao-Ying; Xu, Chao-Yang; Chen, Wen-Jun; Shen, Jian-Guo^*

来源：World Journal of Gastroenterology, 2008, 14(10): 1612-1616.

DOI：10.3748/wjg.14.1612

• heterogeneity
• gastric cancer
• Nm23-h1
• MMP-2
• histological change

AIM: To investigate the changes of histology and expression of MMP-2 and nm23-H1 in primary and metastatic gastric cancer. @@@ METHODS: One hundred and seventy-seven gastric cancer patients with lymph node and/or distal metastasis between 1997 and 2001 were reviewed. Differences in histology of the primary and metastatic gastric cancer were assessed. MMP-2 and nm23-H1 immunoreactivity was compared in 44 patients with tumor infiltration to the serosa layer. @@@ RESULTS: Poorly and moderately differentiated metastatic gastric cancer was found in 88.7% (157/177) and primary gastric cancer in 75.7% (134/177) of the patients. The histological type of metastatic gastric cancer that was not completely in accordance with the preponderant histology of primary gastric cancer was observed in 25 patients (14.1%). MMP-2 immunoreactivity in metastatic gastric cancer was significantly stronger than that in primary gastric cancer, while nm23-H1 immunoreactivity showed no difference in primary and metastatic gastric cancer. @@@ CONCLUSION: Metastatic gastric cancer presents more aggressive histological morphology and higher MMP-2 immunoreactivity than primary gastric cancer. This heterogeneity may elicit a possible mechanism of gastric cancer metastasis.

• 出版日期2008-3-14
• 单位浙江大学