Activity-guided isolation of cytotoxic bis-bibenzyl constituents from Dumortiera hirsuta

作者：Toyota Masao^*; Ikeda Risa; Kenmoku Hiromichi; Asakawa Yoshinori

来源：Journal of Oleo Science, 2013, 62(2): 105-108.

DOI：10.5650/jos.62.105

• liverworts
• Dumortiera hirsuta
• bisbibenzyls
• cytotoxicity

Activity-guided fractionation of the ether extract of Dumortiera hirsute (Japanese liverwort), using cytotoxicity testing with cultured HL 60 and KB cells, resulted in the isolation of a new cytotoxic bis-bibenzyl compound, along with the two known bis-bibenzyls: isomarchantin C and isoriccardin C. The structural determination of the new bis-bibenzyl through extensive NMR spectral data indicated a derivative of marchantin A, which has been isolated from the liverwort Marchantia polymorpha. The cytotoxicity of the bis-bibenzyls was evaluated by the MTT (3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay using cultured HL 60 and KB cells.

• 出版日期2013-2