A Neural Model of the Loss of Self in Schizophrenia

作者：Taylor John Gerald^*

来源：Schizophrenia Bulletin, 2011, 37(6): 1229-1247.

DOI：10.1093/schbul/sbq033

• inner self
• attention
• creation of consciousness
• attentioncopy signal
• attentional blink
• loss of gray matter
• acetylcholine

Numerous researchers have pointed out over the last decades that there is a loss of the sense of the inner self in schizophrenia. In particular, the illuminating article of Sass et al. gives an underpinning explanation of the disease along these lines in each of its 3 manifestations, with positive, negative, or disordered symptoms. The crucial component of the analysis of these researchers is that of various disturbances in ipseity (the ongoing sense of "being there" accompanying all conscious experience) that can occur for a sufferer, giving a framework with which to understand the disease. Such analyses of schizophrenia in terms of distortions of the self go back much earlier. However, the more recent work has become more precise and embracing in terms of seeing most forms of schizophrenia as arising from such distortions. It also provides new ways of looking at and diagnosing the disease. In this article we propose to move the whole analysis closer into the brain itself by means of the CODAM neural network model of consciousness (where CODAM is an acronym for the "COrollary Discharge of Attention Movement" model of consciousness creation, to be described later). This allows both a mechanism to be formulated as to the basic brain-based cause of schizophrenia (with varieties of this cause correlated with the 3 main forms of it) as well as open up possible lines of research to be followed to help ameliorate the attention defects exposed in this approach.

• 出版日期2011-11