Nuclear GPCRs in cardiomyocytes: an insider's view of beta-adrenergic receptor signaling

作者：Vaniotis George; Allen Bruce G; Hebert Terence E^*

来源：American Journal of Physiology - Heart and Circulatory Physiology, 2011, 301(5): H1754-H1764.

DOI：10.1152/ajpheart.00657.2011

• G protein-coupled receptors
• nuclear signaling
• oligomerization
• signaling complexes

Vaniotis G, Allen BG, Hebert TE. Nuclear GPCRs in cardiomyocytes: an insider's view of beta-adrenergic receptor signaling. Am J Physiol Heart Circ Physiol 301: H1754-H1764, 2011. First published September 2, 2011; doi:10.1152/ajpheart.00657.2011.-In recent years, we have come to appreciate the complexity of G protein-coupled receptor signaling in general and beta-adrenergic receptor (beta-AR) signaling in particular. Starting originally from three beta-AR subtypes expressed in cardiomyocytes with relatively simple, linear signaling cascades, it is now clear that there are large receptor-based networks which provide a rich and diverse set of responses depending on their complement of signaling partners and the physiological state. More recently, it has become clear that subcellular localization of these signaling complexes also enriches the diversity of phenotypic outcomes. Here, we review our understanding of the signaling repertoire controlled by nuclear beta-AR subtypes as well our understanding of the novel roles for G proteins themselves in the nucleus, with a special focus, where possible, on their effects in cardiomyocytes. Finally, we discuss the potential pathological implications of alterations in nuclear beta-AR signaling.

• 出版日期2011-11