Neisserial surface lipoproteins: structure, function and biogenesis

作者：Hooda Yogesh; Shin Hyejin E; Bateman Thomas J; Moraes Trevor F

来源：Pathogens and Disease, 2017, 75(2): ftx010.

DOI：10.1093/femspd/ftx010

• surface lipoprotein
• lipoprotein biogenesis
• structure and function
• outer membrane proteins
• Neisseria

The surface of many Gram-negative bacteria contains lipidated protein molecules referred to as surface lipoproteins or SLPs. SLPs play critical roles in host immune evasion, nutrient acquisition and regulation of the bacterial stress response. The focus of this review is on the SLPs present in Neisseria, a genus of bacteria that colonise the mucosal surfaces of animals. Neisseria contains two pathogens of medical interest, namely Neisseria meningitidis and N. gonorrhoeae. Several SLPs have been identified in Neisseria and their study has elucidated key strategies used by these pathogens to survive inside the human body. Herein, we focus on the identification, structure and function of SLPs that have been identified in Neisseria. We also survey the translocation pathways used by these SLPs to reach the cell surface. Specifically, we elaborate on the strategies used by neisserial SLPs to translocate across the outer membrane with an emphasis on Slam, a novel outer membrane protein that has been implicated in SLP biogenesis. Taken together, the study of SLPs in Neisseria illustrates the widespread roles played by this family of proteins in Gram-negative bacteria.

• 出版日期2017-3