A single-nucleotide polymorphism in the p110 beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents

作者：Le Stunff Catherine; Dechartres Agnes; Del Giudice Emanuele Miraglia; Froguel Philippe; Bougneres Pierre^*

来源：Journal of Clinical Endocrinology & Metabolism, 2008, 93(1): 212-215.

DOI：10.1210/jc.2007-1822

Objective: Severe juvenile obesity causes metabolic and cardiovascular complications in adulthood. The catalytic p110 beta subunit of phosphatidyl-inositol-3 kinase is a major effector of insulin action. We studied the p110 beta gene as a candidate gene for association with insulin resistance (IR) and fasting glycemia in severely obese children.
Methods: We conducted an association study in 580 severely obese European children (body mass index > 99.6th centile) and 606 nonobese control children, in whom glucose and insulin were measured in the fasting state. The homeostasis model assessment insulin resistance index was used to estimate IR.
Results: We found that a single-nucleotide polymorphism (rs361072) located in the promoter of the p110 beta gene was associated with fasting glucose (P = 0.0002), insulin (P = 2.6 10(-8)), and homeostasis model assessment insulin resistance index (P = 1 10(-9)) in the severely obese children. The effect of rs361072 was marginal or not significant in nonobese children.
Conclusions: The Callele of rs361072 attenuates IR in superobese children.

• 出版日期2008-1