7,7-Dimethylaporphine and Other Alkaloids from the Bark of Guatteria friesiana

作者：Costa Emmanoel V^*; Pinheiro Maria Lucia B; Maia Beatriz Helena L N S; Marques Francisco A; Ruiz Ana Lucia T G; Marchetti Gabriela M; de Carvalho Joao Ernesto; Soares Milena B P; Costa Cinara O S; Galvao Alexandre F C; Lopes Norberto P; Koolen Hector H F; Bezerra Daniel P; Barison Andersson

来源：Journal of Natural Products, 2016, 79(6): 1524-1531.

DOI：10.1021/acs.jnatprod.5b01037

Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known alkaloids (13-21). The structures of the new alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.

• 出版日期2016-6