New prenylated carbazole alkaloids from Zanthoxylum armatum

作者:Samad Abdul; Badshah Syed; Khan Dilfaraz*; Ali Farman; Amanullah Malik; Hanrahan Jane
来源:Journal of Asian Natural Products Research, 2014, 16(12): 1126-1131.
DOI:10.1080/10286020.2014.967228

摘要

A phytochemical investigation on the ethyl acetate soluble fraction of Zanthoxylum armatum led in the isolation of two new prenylated alkaloids 2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carbaldehyde (1) and methyl-2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carboxylate (2), along with three known lignans cisamin (3), methyl pirpirtol (4), and fargesin (5) and one known alkaloid dictamine (6). Their structures were established on the basis of spectroscopic and crystallographic analysis and by comparison of the data with those in the literature. All the isolated compounds were screened for the DPPH free radical scavenging activity. Compounds 1, 2, and 6 showed profound activity while compounds 3-5 showed moderate activity.

  • 出版日期2014-12-2