A Marriage of Convenience: Combining the Power of Isocyanide-Based Multicomponent Reactions with the Versatility of (Hetero)norbornene Chemistry

作者：Basso Andrea^*; Banfi Luca; Riva Renata

来源：European Journal of Organic Chemistry, 2010, 2010(10): 1831-1841.

DOI：10.1002/ejoc.200901438

• Multicomponent reactions
• Molecular diversity
• Fused-ring systems
• Oxygen heterocycles
• Nitrogen heterocycles

Isocyanide-based multicomponent reactions (I-MCRs) represent a milestone in combinatorial chemistry. Recently, efforts have been made to include I-MCRs in tandem or sequential pathways to synthesise more complex molecules, and the bicyclo[2.2.1]heptene (norbornene) moiety has been demonstrated to be a very versatile scaffold when employed to broaden the scope of the multicomponent approach, making it perfectly suited for diversity-oriented synthesis. In addition to this, the (hetero)norbornane/norbornene scaffold has been shown to influence the stereocontrol of the multicomponent condensation strongly, in some instances making this synthetic approach completely stereoselective. Finally, because of their intrinsic complexity, the resulting molecular entities can find many applications, from biology to polymer science. This review summarises the results obtained in this emerging field.

• 出版日期2010-4