Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner

作者：Rice Teresa C; Armocida Stephanie M; Kuethe Joshua W; Midura Emily F; Jain Ayushi; Hildeman David A; Healy Daniel P; Gulbins Erich; Caldwell Charles C^*

来源：Cellular Immunology, 2017, 313: 25-31.

DOI：10.1016/j.cellimm.2016.12.004

• Burn injury
• T cells
• Butyrate
• Acid sphingomyelinase
• Apoptosis

Following burn injury, a key factor for patients susceptible to opportunistic infections is immune suppression. Butyrate levels are important in maintaining a functional immune system and these levels can be altered after injury. The acid sphingomyelinase (Asm) lipid signaling system has been implicated in a T cell actions with some evidence of being influenced by butyrate. Here, we hypothesized that burn injury changes in butyrate levels would mediate Asm activity and, consequently, T cell homeostasis. We demonstrate that burn injury temporally decreases butyrate levels. We further determined that T cell Asm activity is increased by butyrate and decreased after burn injury. We additionally observed decreased T cell numbers in Asm-deficient, burn-injured, and microbiota-depleted mice. Finally, we demonstrate that butyrate reduced T cell death in an Asm-dependent manner. These data suggest that restoration of butyrate after burn injury may ameliorate the T cell lost observed in burn-injured patients by Asm regulation.

• 出版日期2017-3