Mantle cell lymphoma-like lymphomas in c-myc-3 %26apos; RR/p53(+/-) mice and c-myc-3 %26apos; RR/Cdk4(R24C) mice: differential oncogenic mechanisms but similar cellular origin

作者：Rouaud Pauline; Fiancette Remi; Vincent Fabert Christelle; Magnone Virginie; Cogne Michel; Dubus Pierre; Denizot Yves^*

来源：Oncotarget, 2012, 3(5): 586-593.

DOI：10.18632/oncotarget.474

• Mantle cell lymphoma
• c-myc

Mantle cell lymphoma (MCL) is a malignant lymphoproliferative B-cell disorder that does not occur spontaneously in mice but experimental mice model have been developed. Recently two different mice models prone to develop MCL-like lymphomas were generated: c-myc-3%26apos;RR/Cdk4(R24C) mice and c-myc-3%26apos;RR/p53(+/-) mice. Comparison of their gene expression profiles does not highlight specific differences other than those in relation with their specific mutational status (i.e., Cdk4(R24C) mutation or p53 mutation). We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc-3%26apos;RR/p53(+/-) mice and c-myc-3%26apos;RR/Cdk4(R24C) mice represent a spectrum of the same entity.

• 出版日期2012-5