Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico.

作者：Castillo Quan Jorge I^*; Perez Osorio Julia M

来源：Gaceta Medica de Mexico, 2009, 145(2): 147-150.

• Alzheimer's disease
• nutrigenomics
• polymorphism
• homocysteine
• C677T
• amyloid

The establishment of medical genomics in Mexico offers the possibility to study in a more comprehensive manner the etiological factors of different diseases, providing a global view of the interaction between the genome and the environment. Nutrition is recognized as a significant determinant in several diseases, yet its interaction with polymorphisms, and in general with the genome, has not been properly addressed. Mexico has a high prevalence of polymorphisms of the methylenetetrahydrofolate reductase gene, and in both clinical and basic studies this has been associated with an increased susceptibility of developing Alzheimer's disease. We propose a potential nutrigenomic approach for the study of Alzheimer disease in Mexico.

• 出版日期2009-4