Superacid mediated reactions applied to 4-aminobenzofused sultams and fluorinated 4-aminobenzene sulfonamides synthesis

作者：Liu, Fei; Musadji, Neil Y.; Lecornue, Frederic; Jouannetaud, Marie-Paule; Thibaudeau, Sebastien^*

来源：Tetrahedron, 2010, 66(35): 7112-7118.

DOI：10.1016/j.tet.2010.06.095

• Superacid
• Superelectrophile
• Copper-catalyzed
• Sulfonamide
• Fluorine

A novel series of 4-aminobenzofused sultams was prepared using an efficient synthetic procedure based on superacid mediated reactions followed either by copper-catalyzed coupling or SNAr reactions. The synthetic potential of the method toward the divergent synthesis of novel potent bioactive (fluorinated) aminobenzofused sultams and fluorinated 4-aminobenzene sulfonamides was shown, making it a new valuable process to synthesize a large diversity of compounds in bioactive 4-aminobenzene sulfonamide family.

• 出版日期2010-8-28