科研之友
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摘要
Canine parvovirus (CPV) is a widespread pathogen among canine in China. It has made great veterinary public health burden and economic loss. Three CPV-2 variations, CPV-2a, CPV-2b and CPV-2c, have emerged, however, the CPV-2 variations distribution and the dominant epidemic strain in China are still undetermined. To better understand the epidemiology of CPV in China, the CPV-VP2 gene sequences which had been submitted to GenBank from 1983 to 2011 in China were analyzed and were compared with the representative references from other countries. Phylogenetic trees based on the VP2 sequences were constructed and they showed that the Chinese CPV-2a and CPV-2b strains were close to the Korean and Vietnam strains respectively. It was found that CPV-2a had been the prevalent strain in China and most CPV isolates existed in northeast China. The VP2 protein in CPV-2a and CPV-2b isolated from China had three mutations compared to the American standard strain: 297Ser-Ala, 324Tyr-Ile and 555Ile-Val.
- 出版日期2011-12
- 单位西北农林科技大学
