ASYMMETRIC SYNTHESIS OF 1-ALKYL-2-DEOXYIMINOFURANOSES VIA THE IRIDIUM-CATALYZED INTRAMOLECULAR CYCLIZATION OF AN ALLYLIC CARBONATE

作者：Natori Yoshihiro^*; Kikuchi Shunsuke; Yoshimura Yuichi; Kato Atsushi; Adachi Isao; Takahata Hiroki

来源：Heterocycles, 2012, 86(2): 1401-1417.

DOI：10.3987/COM-12-S(N)99

• 1-Alkyl-2-deoxyiminofuranose
• Ir-Catalyzed Allylic Cyclization
• alpha-Glucosidase Inhibitor

An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step. The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives. The alpha-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.

• 出版日期2012-12-31