Angiographic impact of the GuardWire system on inflated coronary segments after six months: does the distal protection balloon of the GuardWire Plus (TM) lead to restenosis?

作者：Kyono Hiroyuki; Kozuma Ken^*; Muramatsu Toshiya; Suwa Satoshi; Fujita Naoya; Koyama Shiho; Saito Masahiko; Isshiki Takaaki

来源：Eurointervention, 2010, 6(2): 257-260.

DOI：10.4244/EIJV6I2A41

• Angioplasty
• STEMI
• QCA
• occlusion device

Aims: To investigate the consequences of inflating low-pressure balloon occlusion devices in native coronary arteries.
Methods and results: One hundred eighteen segments of 118 patients who were enrolled in the ASPARAGUS study were analysed post-procedure and at six months by means of quantitative coronary angiography. ASPARAGUS was a randomised study to assess the efficacy of the PercuSurge GuardWire system in acute myocardial infarction. Patients were divided into two groups; protection group (group P, n=53) and control group (group C, n=65). Matched 15 mm segments were selected for quantitative coronary angiographies using anatomical landmarks post-procedure and at six months. There were 118 matched QCA analysis (Group P 53, Group C 65). Baseline characteristics were similar between groups. The mean minimal lumen diameter (MLD) post procedure was 1.94 +/- 0.57 mm in group P and 1.92 +/- 0.57 mm in group C. The MLD at six months was 1.98 +/- 0.54 mm in group P and 1.92 0.54 mm in group C. There was virtually no late loss in both group (P: -0.04 +/- 0.38 mm, C: 0.00 +/- 0.38 mm, p=0.561).
Conclusions: The inflation of the low-pressure PercuSurge balloon in native coronary arteries was not associated with angiographic vascular response during the 6-month follow-up. This finding may suggest the safety of using similar technology such as the low-pressure balloon system in human native coronary arteries.

• 出版日期2010-6