Epimeric methylsulfinyladenosine derivatives from the marine ascidian Herdmania momus

作者：Li, Jian Lin; La Kim, Eun; Wang, Haibo; Hong, Jongki; Shin, Sook; Lee, Chong-Kyo; Jung, Jee H.^*

来源：Bioorganic & Medicinal Chemistry Letters, 2013, 23(16): 4701-4704.

DOI：10.1016/j.bmcl.2013.05.097

• Nucleoside derivatives
• Sulfinyl epimers
• Ascidian
• Herdmania momus

Investigation of the secondary metabolites of the ascidian Herdmania momus led to the isolation and characterization of four new nucleoside derivatives (1-4). Structural studies showed that these derivatives represent a series of rare methylsulfinyladenosine derivatives of interconvertible transesterification isomers and/or sulfinyl epimers. The antiviral activities of these rare nucleosides were evaluated against a series of human pathogenic viruses.

• 出版日期2013-8-15
• 单位南通大学