A real-time polymerase chain reaction for the detection of Streptococcus pneumoniae in blood using a mouse model: a potential new "gold standard"

作者：Rouphael Nadine G^*; Atwell Melnick Nikkol; Longo Dana; Whaley Melissa; Carlone George M; Sampson Jackie S; Ades Edwin W

来源：Diagnostic Microbiology and Infectious Disease, 2008, 62(1): 23-25.

DOI：10.1016/j.diagmicrobio.2008.06.002

• real-time PCR
• Streptococcus pneumoniae
• bacteremia
• murine model

Better diagnostics for pneumococcal disease are urgently needed. In a murine model, real-time polymerase chain reaction was superior to conventional culture in detecting pneumococcus in blood, particularly in early disease and after antibiotic administration, and Could distinguish between commensalism and infection.

• 出版日期2008-9