Amide-Directed Ru-Catalyzed Hydrodemethoxylation of ortho-Methoxy-Benzamides and -Naphthamides: A DoM Reaction Counterpart

作者：Zhao Yigang; Snieckus Victor^*

来源：Organic Letters, 2018, 20(10): 2826-2830.

DOI：10.1021/acs.orglett.8b00755

A new ruthenium-catalyzed hydrodemethoxylation of ortho-methoxy-benzamides and -naphthamides involving amide-directed C-OMe bond activation and hydride reduction is disclosed. The reaction is general, proceeding under RuH2(CO)-(PPh3)(3) catalysis using either triethylsilane (Et3SiH) or diisobutylaluminum hydride (DIBAL-H) as the reductant. The corresponding C-N hydrodeamination reaction is also briefly reported.

• 出版日期2018-5-18